Start with A Wrinkle in Time. This is the one book in Madeleine L'Engle's interlocking universe that assumes nothing, and every other book on this path assumes it — the Murry family, the rules of tessering and the particular moral physics that governs all of them are laid down here and never re-explained.
Do not rush the first two chapters. They are stranger and slower than the book's reputation suggests: a long stretch in a kitchen with cocoa and a difficult family before anything cosmic happens. Readers who arrive expecting a space adventure from page one are briefly disappointed and then permanently won over.
The quintet, in publication order
A Wrinkle in Time, then A Wind in the Door, A Swiftly Tilting Planet, Many Waters and An Acceptable Time. Publication order here is also very nearly the characters' chronology, so there is no real controversy to resolve — read them as they came.
What you should expect is inconsistency, because they were written across nearly thirty years and it shows. Each is a different genre: A Wind in the Door goes microscopic and mystical, A Swiftly Tilting Planet is time-travel historical, Many Waters strands the Murry twins in the story of Noah and is the odd one out by some distance, and An Acceptable Time arrives twenty-seven years after the first book with a different protagonist and a much older author's concerns. Recalibrate at the start of each rather than settling into a series rhythm. Many Waters is the one most often skipped, and skipping it costs nothing structurally.
The O'Keefe books
The Arm of the Starfish, Dragons in the waters and A House Like a Lotus follow Meg's daughter Polly and the marine biologist Adam Eddington. They are thrillers rather than fantasies and read considerably faster than the quintet.
Order is a genuine choice here. The Arm of the Starfish and Dragons in the waters are straightforward adventures and belong first. A House Like a Lotus is Polly's own coming-of-age novel and can be read either before An Acceptable Time, if you want her story in her own chronology, or after it, as this path does. Both work: the chronological placement is more coherent, the published placement spoils less.
One plain warning. A House Like a Lotus is considerably more adult than anything in the quintet. It deals with sexual assault, a damaging relationship with an older adult, and Polly's own confusion about both. It is a good book and it is not one to hand to a ten-year-old who has just finished A Wrinkle in Time.
The Austin family
Meet the Austins, A Ring of Endless Light and Troubling a Star are quiet realist family novels with no fantasy element at all. They are shorter and gentler than anything else here, except emotionally: A Ring of Endless Light is a book about a teenager sitting with her grandfather while he dies, and it is by a distance the heaviest thing on this path. Read Meet the Austins first for the family, then A Ring of Endless Light, then Troubling a Star, which is where the two family series openly touch.
Where to stop
Most readers should stop after the quintet, and that is not a criticism — five books is the complete arc and An Acceptable Time closes it. Carry on into the O'Keefe and Austin books if you liked the family more than the physics, which is the honest test. If it was the tessering you loved, the later books will feel like a different writer, because in most of the ways that matter she was. More reading orders for interlocking series are on Discover.
Follow the full ordered path here: A Wrinkle in Time Reading Order and Guide.